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    Kainaat Arora reveals why Sanjay Dutt once advised her not to enter Bollywood

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    ‘Yeh Rishta Kya Kehlata Hai’ actor Rahul Sharma reflects on how boldness is reshaping Indian television Television actor Rahul Sharma, who is currently seen playing the role of Anshuman in “Yeh Rishta Kya Kehlata Hai,” has shared his thoughts on the changing nature of TV content. He pointed out that boldness on television is on the rise, with shows becoming more experimental and less restrained than before. Sharma shared, “There’s no doubt that boldness has increased in films, on OTT platforms, and even on television. But somewhere, it has also started giving people a false impression — that being bold automatically makes you likable or popular. That if you’re bold, people will praise you, follow you, and give you attention. But the reality is, this often leads to objectification, especially for young girls entering the industry. And the boys who are seeing this narrative are also developing a skewed perspective — one where they’re respecting women less and objectifying them more.” He added, “Content reflects society, but now society is also being shaped heavily by content. The constant exposure to certain themes, be it extreme boldness, fast relationships, or dysfunction in families, is influencing young minds. They start believing that what they see is the norm. Parenting has also shifted; soft parenting is more common now. Children are growing up in a very different emotional environment. They are less tolerant, lack resistance, don’t have patience, and honestly, they don’t always understand what truly matters. They're easily influenced and emotionally fragile.” When asked whether audiences today are becoming overexposed—particularly to personal and emotional content onscreen, Rahul Sharma said he believes we are overstimulated in every aspect of life, constantly surrounded by an overwhelming amount of content, visuals, and opinions. “We are overexposed to everything. That’s one of the biggest issues. We’re constantly bombarded with content, visuals, and opinions, and it’s too much. This overexposure is making us impatient and intolerant.” “Yeh Rishta Kya Kehlata Hai,” which is produced under Rajan Shahi’s banner Director’s Kut Production, stars Rohit Purohit and Samridhii Shukla in the lead roles.

    ‘Yeh Rishta Kya Kehlata Hai’ actor Rahul Sharma reflects on how boldness is reshaping Indian television

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    Kainaat Arora reveals why Sanjay Dutt once advised her not to enter Bollywood

    Kainaat Arora reveals why Sanjay Dutt once advised her not to enter Bollywood

    ‘Imlie’ fame Sumbul Touqeer shares how she stays true to herself amid social media pressure

    ‘Imlie’ fame Sumbul Touqeer shares how she stays true to herself amid social media pressure

    ‘Yeh Rishta Kya Kehlata Hai’ actor Rahul Sharma reflects on how boldness is reshaping Indian television Television actor Rahul Sharma, who is currently seen playing the role of Anshuman in “Yeh Rishta Kya Kehlata Hai,” has shared his thoughts on the changing nature of TV content. He pointed out that boldness on television is on the rise, with shows becoming more experimental and less restrained than before. Sharma shared, “There’s no doubt that boldness has increased in films, on OTT platforms, and even on television. But somewhere, it has also started giving people a false impression — that being bold automatically makes you likable or popular. That if you’re bold, people will praise you, follow you, and give you attention. But the reality is, this often leads to objectification, especially for young girls entering the industry. And the boys who are seeing this narrative are also developing a skewed perspective — one where they’re respecting women less and objectifying them more.” He added, “Content reflects society, but now society is also being shaped heavily by content. The constant exposure to certain themes, be it extreme boldness, fast relationships, or dysfunction in families, is influencing young minds. They start believing that what they see is the norm. Parenting has also shifted; soft parenting is more common now. Children are growing up in a very different emotional environment. They are less tolerant, lack resistance, don’t have patience, and honestly, they don’t always understand what truly matters. They're easily influenced and emotionally fragile.” When asked whether audiences today are becoming overexposed—particularly to personal and emotional content onscreen, Rahul Sharma said he believes we are overstimulated in every aspect of life, constantly surrounded by an overwhelming amount of content, visuals, and opinions. “We are overexposed to everything. That’s one of the biggest issues. We’re constantly bombarded with content, visuals, and opinions, and it’s too much. This overexposure is making us impatient and intolerant.” “Yeh Rishta Kya Kehlata Hai,” which is produced under Rajan Shahi’s banner Director’s Kut Production, stars Rohit Purohit and Samridhii Shukla in the lead roles.

    ‘Yeh Rishta Kya Kehlata Hai’ actor Rahul Sharma reflects on how boldness is reshaping Indian television

    Disappointing for both of us, it shouldn’t have happened: Rahul on Pant’s run-out before lunch at Lord’s

    Disappointing for both of us, it shouldn’t have happened: Rahul on Pant’s run-out before lunch at Lord’s

    Namibian female Cheetah Nabha succumbs to injuries

    Namibian female Cheetah Nabha succumbs to injuries

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    EAM Jaishankar to visit China today for SCO meeting

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Study finds drug targets for memory enhancement

newsedgechd by newsedgechd
September 17, 2021
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Specific drug targets within the neural circuits that encode memories and pave the way for significant advances in the treatment of a broad spectrum of brain disorders have been identified by a new University of Bristol-led research.

Loss of memory is a core feature of many neurological and psychiatric disorders including Alzheimer’s disease and schizophrenia. Current treatment options for memory loss are very limited and the search for safe and effective drug therapies has, until now, had limited success. The study was published in Nature Communications.

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The research was done in collaboration with colleagues at the international biopharmaceutical company Sosei Heptares. The findings identify specific receptors for the neurotransmitter acetylcholine that re-route information flowing through memory circuits in the hippocampus. Acetylcholine is released in the brain during learning and is critical for the acquisition of new memories. Until now, the only effective treatment for the symptoms of cognitive or memory impairment seen in diseases such as Alzheimer’s is using drugs that broadly boost acetylcholine. However, this leads to multiple adverse side effects. The discovery of specific receptor targets that have the potential to provide positive effects whilst avoiding negative ones is promising.

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Lead author, Professor Jack Mellor, from the University of Bristol’s Centre for Synaptic Plasticity, said: “These findings are about the fundamental processes that occur in the brain during the encoding of memory and how they may be regulated by brain state or drugs targeting specific receptor proteins. In the long term, the discovery of these specific targets opens up avenues and opportunities for the development of new treatments for the symptoms of Alzheimer’s disease and other conditions with prominent cognitive impairments. The academic-industry partnership is important for these discoveries and we hope to continue working together on these projects.”

Dr Miles Congreve, Chief Scientific Officer at Sosei Heptares, added: “These important studies have helped us to design and select new, exquisitely targeted therapeutic agents that mimic the effects of acetylcholine at specific muscarinic receptors, without triggering the unwanted side effects of earlier and less-well targeted treatments. This approach has the exciting potential to improve memory and cognitive function in patients with Alzheimer’s and other neurological diseases.” “It is fascinating how the brain prioritises different bits of information, working out what is important to encode in memory and what can be discarded. We know there must be mechanisms to pull out the things that are important to us but we know very little about how these processes work. Our future programme of work aims to reveal how the brain does this using acetylcholine in tandem with other neurotransmitters such as dopamine, serotonin and noradrenaline,” said Professor Mellor.

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