High dementia risk to those who feel dizzy on standing

Researchers have found that people who feel dizzy or lightheaded when they stand up may have an increased risk of developing dementia.

The condition, called orthostatic hypotension, occurs when people experience a sudden drop in blood pressure when they stand up, according to the study published in the journal Neurology.

The study found the link with dementia only in people who have a drop in their systolic blood pressure, not in people with only a drop in their diastolic blood pressure or their blood pressure overall.

“People’s blood pressure when they move from sitting to standing should be monitored,” said study author Laure Rouch from the University of California in the US.

“It’s possible that controlling these blood pressure drops could be a promising way to help preserve people’s thinking and memory skills as they age,” Rouch added.

The study involved 2,131 people who were an average age of 73 and did not have dementia when they enrolled. Their blood pressure readings were taken at the start of the study and then one, three and five years later. A total of 15 per cent had orthostatic hypotension, nine per cent had systolic orthostatic hypotension and six per cent had diastolic orthostatic hypotension.

Over the next 12 years, the participants were evaluated to see if anyone developed dementia. A total of 462 people did develop the disease.

According to the study, the people with systolic orthostatic hypotension were nearly 40 per cent more likely to develop dementia than those who did not have the condition.

Fifty of the 192 with systolic orthostatic hypotension, or 26 per cent, developed dementia, compared to 412 of the 1,939 people without it, or 21 per cent. When researchers adjusted for other factors that could affect dementia risk, such as diabetes, smoking and alcohol use, those with systolic orthostatic hypotension were 37 per cent more likely to develop dementia.

The researchers also found that people whose sitting-to-standing systolic blood pressure readings changed the most from a visit to visit were more likely to develop dementia years later than people whose readings were more stable.

The research team noted that the study is observational and does not show cause and effect.